RETAVASE® (reteplase) is a recombinant plasminogen activator which catalyzes the cleavage of endogenous plasminogen to generate plasmin. Plasmin degrades the fibrin matrix of the thrombus, exerting its thrombolytic action.

RETAVASE® (reteplase)
dosing and administration

RETAVASE is supplied as 10 units of lyophilized powder in single-use vials
for reconstitution co-packaged with Sterile Water for Injection, USP.

The only fixed-dose fibrinolytic for acute STEMI—no dosing calculations needed1

RETAVASE is supplied as 10 units of lyophilized powder in single-use vials for reconstitution, co‑packaged with Sterile Water for Injection, USP.


Watch how to reconstitute retavase
immediately before administration

Watch how to reconstitute RETAVASE immediately before administration

Dosing and administration1

Two 10‑unit intravenous injections, 30 minutes apart, are each administered over 2 minutes.

  • Start administration as soon as possible after the onset of STEMI
  • Both 10‑unit IV injections are required for complete treatment
  • No other medication should be injected or infused simultaneously via the same intravenous line or added to the injection solution
RETAVASE Dosing & Administration Guide

Download and print the Dosing & Administration Guide for RETAVASE

Download PDF

Reconstituting and preparing RETAVASE for use1

Reconstitute RETAVASE only with the supplied Sterile Water for Injection. Slight foaming upon reconstitution may occur; if necessary, allow the vial to stand undisturbed for several minutes to allow dissipation of any large bubbles. Prior to administration, inspect the product for particulate matter and discoloration. Solution should appear clear and colorless.2 Use aseptic technique throughout.


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Step1

Uncap spike, vial & prefilled syringe

Image of uncapping spike, vial & prefilled syringe

Step2

Clean vial membrane with alcohol swab

Image of cleaning vial membrane with alcohol swab

Step3

Screw spike to prefilled syringe

Image of screwing spike to prefilled syringe

Step4

Spike vial firmly

Image of spiking vial firmly

Step5

Screw plunger to prefilled syringe

Image of screwing plunger to prefilled syringe

Step6

Transfer water
to vial

Image of transfering water to vial

Step7

Swirl gently

Image of swirling gently - Do not shake

Step8

Exchange prefilled and graduated syringe

Image of exchanging prefilled and graduated syringe

Step9

Withdraw 10 mL

Image of withdrawing 10 mL

Step10

Administer over 2 minutes

Image of administering over 2 minutes